A Whole Organ Culture Model for Intervertebral Disc in the Presence of Nicotine and Cotinine Using Rat Tail Explants in a Rotating Bioreactor
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منابع مشابه
Effects of Morphine Dependency on Intervertebral Disc in the Rat
Background: A large proportion of patients presenting with lumbar disc disease are opium addicts in our region. It was, therefore, hypothesized that morphine might affect the intervertebral disc. We investigated the histological findings of morphine dependency on intervertebral discs in rat. Methods: Forty NMRI adult male rats (230-250 g) placed on ordinary diet and received aqueous solution of...
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The spine is routinely subjected to repetitive complex loading consisting of axial compression, torsion, flexion and extension. Mechanical loading is one of the important causes of spinal diseases, including disc herniation and disc degeneration. It is known that static and dynamic compression can lead to progressive disc degeneration, but little is known about the mechanobiology of the disc su...
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Intervertebral disc (IVD) homeostasis is mediated through a combination of micro-environmental and biomechanical factors, all of which are subject to genetic influences. The aim of this study is to develop and characterize a genetically tractable, ex vivo organ culture model that can be used to further elucidate mechanisms of intervertebral disc disease. Specifically, we demonstrate that IVD di...
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Background Nicotine, cotinine and cadmium are harmful components of cigarettes that have an effect on human reproductive function. Although the effects of cigarette smoke on male reproductive function is characterized in several articles its mechanism of action is still unknown. In the present study, we investigate the effect of nicotine, cotinine and cadmium on human sperm creatine kinase acti...
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The purpose of this study was to gain an improved understanding of the mechanical behavior of the intervertebral disc in the presence and absence of the vertebral endplates. Mechanical behaviors of rat caudal motion segments, vertebrae and isolated disc explants under two different permeability conditions were investigated and viscoelastic behaviors were evaluated using a stretched-exponential ...
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